Description
Full-length recombinant human ERK4 (MAPK4) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number for ERK4 (MAPK4) is NM_002747.
Extracellular signal-regulated kinase 4 (ERK4) is a serine/threonine protein kinase and belongs to atypical MAPKs. Among MAPKs, it is most closely related to the MAP kinase ERK3, with 73% amino acid identity within the kinase catalytic domain. The precise role of ERK4 is still unclear. It phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, and may promote entry in the cell cycle